BPC-157
Synthetic 15-amino acid peptide derived from human gastric juice with remarkable tissue-healing, anti-inflammatory, and cytoprotective properties across multiple organ systems.
⚡ Executive Summary
BPC-157 (Body Protection Compound-157) is a research peptide known for accelerating repair of muscles, tendons, bones, and gut ulcers. It works by promoting angiogenesis, boosting growth factors, and reducing inflammation. In animal studies, it shows remarkable healing without significant side effects. Not FDA-approved — remains experimental and is banned in sports by WADA.
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Overview
🧬 What is BPC-157?
BPC-157 is a synthetic 15-amino acid peptide first derived from a protective protein found in human gastric juice.
It acts as a broad-spectrum cytoprotective and pro-angiogenic agent, orchestrating multiple healing pathways simultaneously.
🎯 Key Actions
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🩸
Angiogenesis — promotes new blood vessel growth
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📈
Growth factors — upregulates VEGF, ERK, AKT
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🔥
Anti-inflammatory — reduces IL-6, TNF-α, COX-2
Research only: BPC-157 is not FDA-approved and is banned in competitive sports by WADA. All evidence is from animal studies — human clinical trials are lacking.
Entity Properties
| Aliases | BPC-157, Body Protection Compound-157, PL-14736, Bepecin |
|---|---|
| Sequence |
Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
|
| Length | 15 amino acids |
| Molecular Weight | ~1419.5 Da |
| CAS Number | 137525-51-0 |
| Family | Gastric pentadecapeptide, cytoprotective peptide |
| Diluent(s) | Bacteriostatic water (0.9% benzyl alcohol) or sterile saline |
| Concentration | 5 mg + 2 mL = ~2.5 mg/mL; 10 mg + 2 mL = ~5 mg/mL |
| Storage (dry) | 2–8°C refrigerated; stable for months |
| Storage (solution) | 2–8°C; use within 4–6 weeks; avoid freeze-thaw |
Mechanism of Action
🧠 How does BPC-157 work?
BPC-157 works by activating multiple healing pathways simultaneously — a “broad-spectrum” repair peptide. It promotes blood vessel formation (VEGF↑), triggers cell survival pathways (ERK1/2, AKT), and boosts growth hormone receptor expression in tendon cells.
It also increases nitric oxide synthase (NOS) activity for improved blood flow and quenches inflammation by lowering IL-6, TNF-α, COX-2, and myeloperoxidase.
🩸 Angiogenesis
Increases VEGF → new blood vessels → enhanced nutrient delivery to injured tissues
📈 Growth Signals
Upregulates ERK1/2, AKT, and growth hormone receptor → cell proliferation & migration
🔥 Anti-Inflammatory
Reduces IL-6, TNF-α, COX-2, myeloperoxidase → less swelling and pain
Multi-modal action: BPC-157 protects cells from stress, stimulates growth factors, opens blood vessels, and dials down inflammation — explaining why it benefits diverse injury types from tendons to gut ulcers.
Research Benefits
🐭 Preclinical Findings (Animal Studies)
Tendon & Ligament
Accelerated Achilles tendon repair; stronger fiber alignment; restored joint stability in ligament injuries
Muscle Regeneration
Faster muscle fiber regeneration; larger fibers, less atrophy; quicker return of strength
Bone & Joint
Supported bone healing; as effective as bone grafts in non-union fracture models
GI Protection
Potent anti-ulcer effects; faster ulcer healing; protection against NSAID-induced gut injury
Neuroprotection
Reduced brain damage in stroke/trauma models; modulates serotonin/dopamine pathways
Safety Profile
No significant toxicity at wide dose ranges; no organ damage in animal studies
Important: All benefits are from animal studies. Human outcomes may differ. No large-scale clinical trials have been completed. A Phase 1 trial is testing oral BPC-157 for ulcerative colitis.
Dosage & Administration
Research use only. No official human dose guidelines exist. The following is educational based on animal data and common research protocols.
📊 Dosing Reference
| Typical Dose | 200–500 µg per injection |
|---|---|
| Starting Dose | ~250–300 µg once daily (beginners) |
| Route | Subcutaneous injection (subQ) |
| Frequency | Once or twice daily |
| Cycle Length | 2–4 weeks typical; up to 6 weeks |
| Half-life | ~30 minutes (short) |
Gather Supplies
BPC-157 vial, bacteriostatic water, insulin syringes, alcohol swabs
Reconstitute
Add 2 mL bac water to 5 mg vial = 2.5 mg/mL. Swirl gently, don’t shake
Calculate Dose
250 µg = 0.1 mL (10 units) at 2.5 mg/mL concentration
Inject SubQ
Clean site with alcohol; inject into belly fat or near injury at 45° angle
Store Solution
Refrigerate at 2–8°C; use within 4–6 weeks
Rotate Sites
Alternate injection sites daily to avoid irritation
BPC-157 vs TB-500
Both peptides accelerate healing but work through different mechanisms. They are often used together for complementary effects.
BPC-157
Cytoprotective + anti-inflammatory. Promotes angiogenesis, nitric oxide, growth factors. Short half-life (~30 min) → daily dosing. Best for gut healing, tendon/ligament repair, localized injuries.
TB-500
Cell migration + wound healing. Strong angiogenesis, collagen deposition. Longer half-life → less frequent dosing (1-2x/week). Best for skin wounds, muscle tears, cardiac repair.
Synergy: BPC-157 + TB-500 is a common combination — BPC handles inflammation and protection while TB-500 drives cell migration and regeneration. Neither is FDA-approved; both are banned in sports.
FAQ
Bottom line: BPC-157 is a promising research peptide with remarkable healing properties across tendons, muscles, bones, and gut in animal studies. Its multi-modal mechanism (angiogenesis + anti-inflammation + growth factors) explains its broad benefits. However, it remains experimental with no FDA approval — use cautiously and for research purposes only.